Page last updated: 2024-12-10

(2-chlorophenyl)-(5-hydroxy-3-methyl-5-phenyl-4H-pyrazol-1-yl)methanone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

(2-chlorophenyl)-(5-hydroxy-3-methyl-5-phenyl-4H-pyrazol-1-yl)methanone is a complex organic molecule. While I don't have access to a database of specific chemical compounds or research findings, I can break down the information given and explain why it's important for research in general.

**Let's analyze the structure:**

* **(2-chlorophenyl)-(5-hydroxy-3-methyl-5-phenyl-4H-pyrazol-1-yl)methanone:**
* **(2-chlorophenyl):** This indicates a phenyl ring (a six-membered carbon ring with alternating single and double bonds) with a chlorine atom attached to the second carbon.
* **(5-hydroxy-3-methyl-5-phenyl-4H-pyrazol-1-yl):** This describes a pyrazole ring. Pyrazole is a five-membered ring containing two nitrogen atoms and a carbon. In this case, it has:
* A hydroxyl group (-OH) attached to the fifth carbon.
* A methyl group (-CH3) attached to the third carbon.
* A phenyl ring attached to the fifth carbon.
* The '4H' indicates the presence of a hydrogen atom on the fourth carbon.
* **methanone:** This is a ketone functional group (C=O).

**Why is it important for research?**

Many organic compounds with complex structures like this one are investigated for potential biological activity. This is because:

* **Pyrazoles:** These are frequently found in pharmaceuticals and agrochemicals. They possess diverse biological activities, including anti-inflammatory, analgesic, anti-microbial, and anti-cancer properties.
* **Ketones:** These are common functional groups that can influence a molecule's interaction with biological systems. They can also be modified for various applications.
* **Substituents:** The presence of chlorine, methyl, and phenyl groups adds to the compound's complexity and can influence its biological activity and physical properties.

**Potential Research Areas:**

The specific molecule you mentioned could be investigated for:

* **Pharmaceutical applications:** As a potential drug candidate for various diseases or conditions.
* **Agrochemical applications:** As a pesticide, herbicide, or fungicide.
* **Material science:** For its potential properties as a polymer, dye, or other material.

**Key takeaway:** Complex organic molecules like (2-chlorophenyl)-(5-hydroxy-3-methyl-5-phenyl-4H-pyrazol-1-yl)methanone are studied to explore their potential applications in medicine, agriculture, and other fields.

To find out more about the specific research related to this molecule, you would need to search for it in scientific databases such as PubMed, Web of Science, or Google Scholar.

Cross-References

ID SourceID
PubMed CID2868929
CHEMBL ID1566760
CHEBI ID121655

Synonyms (20)

Synonym
(2-chlorophenyl)-(5-hydroxy-3-methyl-5-phenyl-4h-pyrazol-1-yl)methanone
CBMICRO_014078
5792-72-3
BIM-0014070.P001
EU-0010106
MLS001202722
smr000514891
(2-chloro-phenyl)-(5-hydroxy-3-methyl-5-phenyl-4,5-dihydro-pyrazol-1-yl)-methanone
CHEBI:121655
AKOS000592116
STK868230
(2-chlorophenyl)(5-hydroxy-3-methyl-5-phenyl-4,5-dihydro-1h-pyrazol-1-yl)methanone
CB09375
smsf0007837
HMS2816C10
AKOS021998678
CHEMBL1566760
DTXSID30386682
Q27210216
1-(2-chlorobenzoyl)-3-methyl-5-phenyl-4,5-dihydro-1h-pyrazol-5-ol
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (2)

ClassDescription
carbonyl compoundAny compound containing the carbonyl group, C=O. The term is commonly used in the restricted sense of aldehydes and ketones, although it actually includes carboxylic acids and derivatives.
organohalogen compoundA compound containing at least one carbon-halogen bond (where X is a halogen atom).
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (6)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
glp-1 receptor, partialHomo sapiens (human)Potency10.00000.01846.806014.1254AID624417
apical membrane antigen 1, AMA1Plasmodium falciparum 3D7Potency1.99530.707912.194339.8107AID720542
67.9K proteinVaccinia virusPotency7.94330.00018.4406100.0000AID720579
P53Homo sapiens (human)Potency70.79460.07319.685831.6228AID504706
chromobox protein homolog 1Homo sapiens (human)Potency100.00000.006026.168889.1251AID540317
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency6.69460.00798.23321,122.0200AID2546; AID2551
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (13)

Assay IDTitleYearJournalArticle
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's3 (60.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.56

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.56 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.36 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.56)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]