Compounds > (1,5-anhydro-7-amino-2,7-dideoxyheptopyranosyl)carboxylate
Page last updated: 2024-12-10
(1,5-anhydro-7-amino-2,7-dideoxyheptopyranosyl)carboxylate
Description
You're asking about a very specific and complex molecule, and it's not exactly common knowledge.
**(1,5-Anhydro-7-amino-2,7-dideoxyheptopyranosyl)carboxylate** is a modified sugar with a unique structure. It's worth breaking down its parts to understand its significance:
* **1,5-Anhydro:** This indicates a ring structure with an internal ether bond between the 1st and 5th carbon atoms. This is a characteristic feature of certain sugars.
* **7-amino-2,7-dideoxyheptopyranosyl:** This part tells us it's a heptose (a 7-carbon sugar) with a modified pyranose ring structure. It has an amino group (-NH2) at the 7th carbon and lacks an oxygen on the 2nd carbon.
* **carboxylate:** This denotes the presence of a carboxyl group (-COO-) attached to the molecule.
**Why is this structure important in research?**
The specific modification with the 1,5-anhydro ring and the amino group at the 7th carbon makes this sugar unique. This structure is often found in complex bacterial cell wall components and plays a critical role in:
* **Bacterial cell wall synthesis:** This molecule can be a building block for specific bacterial cell wall structures. Understanding its synthesis and function is important for developing new antibiotics that target bacterial cell wall formation.
* **Immunological studies:** The unique structure of this sugar can trigger immune responses, making it relevant for research on bacterial infections, vaccines, and immune modulation.
**Finding more information:**
To find more specific information, you would need to search for:
* **1,5-anhydro-7-amino-2,7-dideoxyheptopyranosylcarboxylate** in scientific databases like PubMed or Google Scholar.
* **Bacterial cell wall biosynthesis research:** This would likely lead you to research related to specific bacterial species or types of cell walls where this sugar is found.
* **Immunological studies on bacterial cell wall components:** This might provide insights into the role of this sugar in immune recognition and response.
**Important Note:** The exact significance of this specific sugar molecule will depend on the context of the research. It's not a universal building block for all bacterial cell walls, and its importance will vary based on the specific bacterial species or research focus.
(1,5-anhydro-7-amino-2,7-dideoxyheptopyranosyl)carboxylate: inhibitor of CMP-KDO synthetase; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
ID Source | ID |
PubMed CID | 3035904 |
CHEMBL ID | 160423 |
SCHEMBL ID | 10755276 |
MeSH ID | M0151489 |
Synonyms (12)
Synonym |
aadhc |
CHEMBL160423 |
(2s,4r,5r,6r)-6-[(1r)-2-amino-1-hydroxyethyl]-4,5-dihydroxyoxane-2-carboxylic acid |
106174-48-5 |
(1,5-anhydro-7-amino-2,7-dideoxyheptopyranosyl)carboxylate |
alpha-c-(1,5-anhydro-7-amino-2,7-dideoxy-d-manno-heptopyranosyl)carboxylate |
d-glycero-d-talo-octonic acid, 8-amino-2,6-dihydro-3,8-dideoxy- |
8-amino-2,6-dihydro-3,8-dideoxy-d-glycero-d-talo-octonic acid |
nh2dkdo |
8-amino-2,6-anhydro-3,8-dideoxy-d-glycero-d-talo-octonic acid |
SCHEMBL10755276 |
DTXSID70147537 |
Bioassays (3)
Assay ID | Title | Year | Journal | Article |
AID45756 | Activity against CMP-KDO synthetase-KDO-lipid A transferase (CKS-KLT) assay from Escherichia coli D21 | 1989 | Journal of medicinal chemistry, May, Volume: 32, Issue:5
| Synthesis of 8-substituted derivatives of the 2-deoxy analogue of 3-deoxy-beta-D-manno-2-octulopyranosonic acid (2-deoxy-beta-KDO) as inhibitors of 3-deoxy-D-manno-octulosonate cytidylyltransferase. |
AID45904 | In vitro inhibition of 3-deoxy-D-manno-2-octulosonate cytidylyltransferase (CMP-KDO) synthetase a key enzyme in the biosynthesis of the lipopolysaccharide (LPS) of Gram-negative bacteria | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3
| A novel prodrug of an impermeant inhibitor of 3-deoxy-D-manno-2-octulosonate cytidylyltransferase has antibacterial activity. |
AID45766 | Activity against CMP-KDO synthetase (CKS) from Escherichia coli D21,the compound gave rise to a strongly interfering absorption in the thiobarbituric acid assay | 1989 | Journal of medicinal chemistry, May, Volume: 32, Issue:5
| Synthesis of 8-substituted derivatives of the 2-deoxy analogue of 3-deoxy-beta-D-manno-2-octulopyranosonic acid (2-deoxy-beta-KDO) as inhibitors of 3-deoxy-D-manno-octulosonate cytidylyltransferase. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (4)
Timeframe | Studies, This Drug (%) | All Drugs % |
pre-1990 | 3 (75.00) | 18.7374 |
1990's | 1 (25.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 12.53
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
Metric | This Compound (vs All) |
---|
Research Demand Index | 12.53 (24.57) | Research Supply Index | 1.79 (2.92) | Research Growth Index | 4.32 (4.65) | Search Engine Demand Index | 0.00 (26.88) | Search Engine Supply Index | 0.00 (0.95) |
| |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 5 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |