Page last updated: 2024-12-10

(1,5-anhydro-7-amino-2,7-dideoxyheptopyranosyl)carboxylate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

You're asking about a very specific and complex molecule, and it's not exactly common knowledge.

**(1,5-Anhydro-7-amino-2,7-dideoxyheptopyranosyl)carboxylate** is a modified sugar with a unique structure. It's worth breaking down its parts to understand its significance:

* **1,5-Anhydro:** This indicates a ring structure with an internal ether bond between the 1st and 5th carbon atoms. This is a characteristic feature of certain sugars.
* **7-amino-2,7-dideoxyheptopyranosyl:** This part tells us it's a heptose (a 7-carbon sugar) with a modified pyranose ring structure. It has an amino group (-NH2) at the 7th carbon and lacks an oxygen on the 2nd carbon.
* **carboxylate:** This denotes the presence of a carboxyl group (-COO-) attached to the molecule.

**Why is this structure important in research?**

The specific modification with the 1,5-anhydro ring and the amino group at the 7th carbon makes this sugar unique. This structure is often found in complex bacterial cell wall components and plays a critical role in:

* **Bacterial cell wall synthesis:** This molecule can be a building block for specific bacterial cell wall structures. Understanding its synthesis and function is important for developing new antibiotics that target bacterial cell wall formation.
* **Immunological studies:** The unique structure of this sugar can trigger immune responses, making it relevant for research on bacterial infections, vaccines, and immune modulation.

**Finding more information:**

To find more specific information, you would need to search for:

* **1,5-anhydro-7-amino-2,7-dideoxyheptopyranosylcarboxylate** in scientific databases like PubMed or Google Scholar.
* **Bacterial cell wall biosynthesis research:** This would likely lead you to research related to specific bacterial species or types of cell walls where this sugar is found.
* **Immunological studies on bacterial cell wall components:** This might provide insights into the role of this sugar in immune recognition and response.

**Important Note:** The exact significance of this specific sugar molecule will depend on the context of the research. It's not a universal building block for all bacterial cell walls, and its importance will vary based on the specific bacterial species or research focus.

(1,5-anhydro-7-amino-2,7-dideoxyheptopyranosyl)carboxylate: inhibitor of CMP-KDO synthetase; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID3035904
CHEMBL ID160423
SCHEMBL ID10755276
MeSH IDM0151489

Synonyms (12)

Synonym
aadhc
CHEMBL160423
(2s,4r,5r,6r)-6-[(1r)-2-amino-1-hydroxyethyl]-4,5-dihydroxyoxane-2-carboxylic acid
106174-48-5
(1,5-anhydro-7-amino-2,7-dideoxyheptopyranosyl)carboxylate
alpha-c-(1,5-anhydro-7-amino-2,7-dideoxy-d-manno-heptopyranosyl)carboxylate
d-glycero-d-talo-octonic acid, 8-amino-2,6-dihydro-3,8-dideoxy-
8-amino-2,6-dihydro-3,8-dideoxy-d-glycero-d-talo-octonic acid
nh2dkdo
8-amino-2,6-anhydro-3,8-dideoxy-d-glycero-d-talo-octonic acid
SCHEMBL10755276
DTXSID70147537
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (3)

Assay IDTitleYearJournalArticle
AID45756Activity against CMP-KDO synthetase-KDO-lipid A transferase (CKS-KLT) assay from Escherichia coli D211989Journal of medicinal chemistry, May, Volume: 32, Issue:5
Synthesis of 8-substituted derivatives of the 2-deoxy analogue of 3-deoxy-beta-D-manno-2-octulopyranosonic acid (2-deoxy-beta-KDO) as inhibitors of 3-deoxy-D-manno-octulosonate cytidylyltransferase.
AID45904In vitro inhibition of 3-deoxy-D-manno-2-octulosonate cytidylyltransferase (CMP-KDO) synthetase a key enzyme in the biosynthesis of the lipopolysaccharide (LPS) of Gram-negative bacteria1989Journal of medicinal chemistry, Mar, Volume: 32, Issue:3
A novel prodrug of an impermeant inhibitor of 3-deoxy-D-manno-2-octulosonate cytidylyltransferase has antibacterial activity.
AID45766Activity against CMP-KDO synthetase (CKS) from Escherichia coli D21,the compound gave rise to a strongly interfering absorption in the thiobarbituric acid assay1989Journal of medicinal chemistry, May, Volume: 32, Issue:5
Synthesis of 8-substituted derivatives of the 2-deoxy analogue of 3-deoxy-beta-D-manno-2-octulopyranosonic acid (2-deoxy-beta-KDO) as inhibitors of 3-deoxy-D-manno-octulosonate cytidylyltransferase.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (4)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (75.00)18.7374
1990's1 (25.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.53

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.53 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.53)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]