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quinone
Compounds having a fully conjugated cyclic dione structure, such as that of benzoquinones, derived from aromatic compounds by conversion of an even number of -CH= groups into -C(=O)- groups with any necessary rearrangement of double bonds (polycyclic and heterocyclic analogues are included).
ChEBI ID: 36141
Members (2)
| Member | Definition | Role |
|---|
| amrubicin | A synthetic anthracycline antibiotic with molecular formula C25H25NO9. A specific inhibitor of topoisomerase II, it is used (particularly as the hydrochloride salt) in the treatment of cancer, especially lung cancer, where it is a prodrug for the active metabolite, ambrucinol. | amrubicin |
| amrubicinol | A diastereoisomeric mixture resulting from the formal reduction of the acetyl group at position 9 of amrubicin to the corresponding 1-hydroxyethyl group. The active metabolite of amrubicin in lung cancer patients. | amrubicinol |
Research
Studies (222)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|
| pre-1990 | 6 (2.70) | 18.7374 |
| 1990's | 17 (7.66) | 18.2507 |
| 2000's | 66 (29.73) | 29.6817 |
| 2010's | 116 (52.25) | 24.3611 |
| 2020's | 17 (7.66) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|
| Trials | 81 (31.64%) | 5.53% |
| Reviews | 25 (9.77%) | 6.00% |
| Case Studies | 30 (11.72%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 120 (46.88%) | 84.16% |