pyridobenzimidazole

An organic heterotricyclic compound that is any benzimidazole ortho-fused to a pyridine ring.

ChEBI ID: 176507

Members (6)

Member	Definition	Role
1-(diethylamino)-3-methyl-4-pyrido[1,2-a]benzimidazolecarbonitrile		1-(diethylamino)-3-methyl-4-pyrido[1,2-a]benzimidazolecarbonitrile
2-chloro-5-methyl-1-oxo-3-phenyl-4-pyrido[1,2-a]benzimidazolecarbonitrile		2-chloro-5-methyl-1-oxo-3-phenyl-4-pyrido[1,2-a]benzimidazolecarbonitrile
3-methyl-1-(3-propan-2-yloxypropylamino)-4-pyrido[1,2-a]benzimidazolecarbonitrile		3-methyl-1-(3-propan-2-yloxypropylamino)-4-pyrido[1,2-a]benzimidazolecarbonitrile
3-propyl-1-(2-pyridinylmethylamino)-4-pyrido[1,2-a]benzimidazolecarbonitrile		3-propyl-1-(2-pyridinylmethylamino)-4-pyrido[1,2-a]benzimidazolecarbonitrile
7,8-dichloropyrido[1,2-a]benzimidazole		7,8-dichloropyrido[1,2-a]benzimidazole
iFSP1	A member of the class of pyridobenzimidazoles that is pyrido[1,2-a]benzimidazole substituted by amino, cyano, 4-methylphenyl, and cyano groups at positions 1, 2, 3 and 4, respectively. It is a potent inhibitor of ferroptosis suppressor protein 1 (FSP1) with EC50 of 103 nM. It induces ferroptosis in GPX4 knockout cells that overexpress FSP1.	iFSP1