A member of the class of piperidines that is 3-(piperidin-1-yl)propan-1-ol in which one of the hydrogen atoms at the 1-position is substituted by cyclopentyl, and the other is substituted by phenyl. A central anticholinergic, it is used as its hydrochloride salt in the management and treatment of Parkinson's disease.
ChEBI ID: 59692
There are 2 compounds belonging to this class, involving 1 studies.
Member | Definition | Role |
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(S)-cycrimine | The (S)-enantiomer of cycrimine. | |
(R)-cycrimine | The (R)-enantiomer of cycrimine. |
Pre-1990 | 1990-2000 | 2001-2010 | 2011-2020 | Post-2020 |
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0 | 1 | 0 | 0 | 0 |
Article |
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Comparative molecular field analysis of haptens docked to the multispecific antibody IgE(Lb4)
Using comparative molecular field analysis (CoMFA), three-dimensional quantitative structure-activity relationships were developed for 27 haptens which bind to the monoclonal antibody IgE(Lb4). In order to obtain an alignment for these structurally very diverse antigens, the compounds were docked to a previously modeled receptor structure using the automated docking program AUTODOCK (Goodsell, D.S.; Olson, A.J. Proteins: Struct., Funct., Genet. 1990, 8, 195-202). Remarkably, this alignment method yielded highly consistent QSAR models, as indicated by the corresponding cross-validated r2 values (0.809 for a model with carbon as probe atom, 0.773 for a model with hydrogen as probe atom). Conventional alignment failed in providing a basis for self-consistent CoMFAs. Amino acids Tyr H 50, Tyr H 52, and Trp H 95 of the receptor appeared to be of crucial importance for binding of various antigens. These findings are consistent with earlier considerations of aromatic residues being responsible for the multispecificity of certain immunoglobulins. |