cortistatins

Any member of a class of steroidal alkaloids obtained from the marine sponge Corticium simplex, with a basic skeleton that is (5R,8beta)-5,8-epoxy-9,19-cyclo-9,10-secoandrostane, bearing a dimethylamino substituent at position 3 and an isoquinolin-7-yl or isoquinolin-7-yl-derived substituent at position 17. They selectively inhibit proliferation of human umbilical vein endothelial cells (HUVECs).

ChEBI ID: 67169

Members (1)

Member	Definition	Role
cortistatin a	A member of the class of cortistatins that is substituted by hydroxy groups at positions 1 and 2, a dimethylamino group at the 3alpha position and an isoquinolin-7-yl group at the 17 position, with double bonds at the 9-11 and 10-19 positions (the 1R,2R,17beta enantiomer).	cortistatin A

Research

Studies (29)

Timeframe	Studies, Drugs in This Class (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	8 (27.59)	29.6817
2010's	21 (72.41)	24.3611
2020's	0 (0.00)	2.80

Study Types

Publication Type	Studies, Drugs in This Class (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	3 (10.34%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	26 (89.66%)	84.16%