A methionine sulfoximine in which the amino group has S-stereochemistry.
ChEBI ID: 28490
There are 3 compounds belonging to this class, involving 1 studies.
| Member | Definition | Role |
|---|---|---|
| (2S,5R)-methionine-sulfoximine | ; | |
| (2S,5S)-methionine-sulfoximine |
| Pre-1990 | 1990-2000 | 2001-2010 | 2011-2020 | Post-2020 |
|---|---|---|---|---|
| 0 | 0 | 0 | 1 | 0 |
| Article |
|---|
Nanomolar inhibitors of Mycobacterium tuberculosis glutamine synthetase 1: synthesis, biological evaluation and X-ray crystallographic studies.
A series of imidazo[1,2-a]indeno[1,2-e]pyrazin-4-ones that potently inhibit M. tuberculosis glutamine synthetase (GlnA1) has been identified by high throughput screening. Exploration of this series was performed owing to a short chemistry program. Despite possibly nanomolar inhibitions, none of these compounds was active on whole cell Mtb, suggesting that GlnA1 may not be a suitable target to find new anti-tubercular drugs. |